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Hujun Yu

As seen in: Nature, BioRxiv
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Articles by Hujun Yu

Convergent evolution of scavenger cell development at brain borders - Nature

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By Stefanie Dudczig, Hujun Yu, Lee Miles, Andrew Pask, Jana Vukovic, Anne K. Lagendijk, Kelly Smith, Peter Currie, Andrea U. Gaudi, Sayali Chowdhary, Robert J. Bryson-Richardson
| Nature Verified
Abstract The vertebrate central nervous system is protected by the blood–brain barrier and meningeal membranes, which ensure immune privilege1. In the mammalian brain, microglia and barrier-associated or border-associated macrophages (BAMs) provide immune surveillance and scavenge wastes2, yet how evolution shaped immune-cell diversity and function is not understood.
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Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds

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By Virginia Panara, Di Peng, Hujun Yu, Karin Staxang
| BioRxiv
Abstract Lymphatic vessels play a role in several physiological and pathological processes including tissue fluid homeostasis, dietary fat absorption, immunosurveillance, and immunomodulation. During embryonic development, lymphatic endothelial cell (LEC) precursors are distinguished from blood endothelial cells by the expression of the transcription factor Prospero-related homeobox 1 (PROX1). PROX1 is essential for lymphatic vascular network formation in mouse and zebrafish.
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