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Abstract Invasive lobular carcinoma (ILC) is characterized by E-cadherin loss resulting from CDH1 inactivation, but discordance among morphology, immunohistochemistry (IHC), and molecular findings can complicate diagnosis. We integrated histology, IHC, DNA sequencing, and whole-transcriptome sequencing (WTS) to clarify such discrepancies. Among 126 clinically sequenced breast cancers, 15 were selected based on ILC diagnosis or the presence of CDH1 mutation.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
