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Hyewon Ko

As seen in: Nature, ACS Publications
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Articles by Hyewon Ko

Combating small extracellular vesicle–mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides

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By Chan Kim, Hyewon Ko, Jae Lee, So Hee Kim, Minsung Park, Chang Hyun Lee, Jung Shin, Soyoung Son, Jeongjin Lee, Sohyun Cho, Jiyeon Kim, Min Kim, Joshua A. Jackman, Jae Park, Sol Shin, Heegun Kang, Joonsuk Chang, Won Ho Jang
| Nature Verified
Abstract Tumor cell-derived small extracellular vesicles (TDEs) play a critical role in immune evasion, including the establishment of an immunosuppressive tumor microenvironment (TME), and form a substantial barrier to effective cancer immunotherapy. Here, we introduce the ExoPERM (pH-enabled rupture of exosome membranes) strategy, a pH-responsive system based on small extracellular vesicle (EV)-disrupting alpha-helical peptides that selectively target small EVs localized within the TME.
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Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

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By Chan Kim, Eun Sook Lee, Hyewon Ko, Soyoung Son
| ACS Publications
Download Hi-Res ImageDownload to MS-PowerPointCite This:Chem. Mater. 2024, XXXX, XXX This article has not yet been cited by other publications.
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