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I. Opitz

As seen in: Nature
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Articles by I. Opitz

Co-alterations associated with resistance to EGFR inhibitors in advanced EGFR-positive NSCLC: insights from the precision oncology program in two large international real-world cohorts

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By G. Gut, M. Nowak, L. Alix Kaczmarek, S. Ulrich, M. Guckenberger, LA Boos, C. Doerig, E. Camarillo-Retamosa, M. Sarwary, S. Rizzo, N. Miglino, L. Fábregas-Ibáñez, C. Früchtenicht, M. Zoche, B. Bodenmiller, S. Chevrier, AS Eklund, S. Rahmani-Khajouei, GC Berardo, K. Bosshard, W. Archey, M. Bodmer, D. Glinz, I. Opitz, L. Hempel, I. Stiefel, P. Rahimzadeh, B. Gosztonyi, U. Richter, L. Bankel, A. Wicki
| Nature Verified
Abstract EGFR inhibitors (EGFRi), alone or combined with chemotherapy or bispecific antibodies, are standard first-line therapy for advanced EGFR-mutant NSCLC, but their efficacy is limited by heterogeneous resistance mechanisms. To define the impact of genetic co-alterations, we analyzed two complementary real-world cohorts.
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