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I. Poggiolini on Muck Rack

I. Poggiolini

As seen in: Color Research & Application
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Articles by I. Poggiolini

Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease

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By C. Ruffmann, N. Bengoa‐Vergniory, I. Poggiolini, D. Ritchie
| Color Research & Application Verified
Gastrointestinal (GI) α‐synuclein (aSyn) detection as a potential biomarker of Parkinson's disease (PD) is challenged by conflicting results of recent studies. To increase sensitivity and specificity, we applied three techniques to detect different conformations of aSyn in GI biopsies obtained from a longitudinal, clinically well‐characterized cohort of PD patients and healthy controls (HC). A total of 163 tissue blocks were collected from 51 PD patients (113 blocks) and 21 HC (50 blocks).
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Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease

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By C. Ruffmann, D. Ritchie, N. Bengoa‐Vergniory, I. Poggiolini
| Color Research & Application Verified
This study was designed to tackle the limitations and issues emerging from previous studies on GI aSyn detection as a potential biomarker for PD. We detected aSyn in paraffin‐embedded GI biopsies from longitudinally followed PD patients and healthy controls (HC) participating in the Oxford Discovery study 23 using three different techniques: conventional IHC, our recently developed Proximity Ligation Assay for aSyn (AS‐PLA) 24 and Paraffin Embedded Tissue Blot for aSyn (AS‐PET‐blot) 25 .
Open in Who Shared Issue with article?

Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease

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By C. Ruffmann, N. Bengoa‐Vergniory, I. Poggiolini, D. Ritchie
| Color Research & Application Verified
Abstract Aims Gastrointestinal (GI) α‐synuclein (aSyn) detection as a potential biomarker of Parkinson's disease (PD) is challenged by conflicting results of recent studies. To increase sensitivity and specificity, we applied three techniques to detect different conformations of aSyn in GI biopsies obtained from a longitudinal, clinically well‐characterized cohort of PD patients and healthy controls (HC).
Open in Who Shared Issue with article?
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