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1 Introduction Langerhans cell histiocytosis (LCH) is a clonal myeloid neoplasm characterized by the proliferation and accumulation of CD1a+ and CD207+ dendritic cells, resulting in granulomatous lesions that can affect virtually any organ system [1-3]. LCH is rare, with incidence in children under 15 years of age estimated at 4.1 to 4.6 cases per million per year, with lower incidence rates in adults at approximately 1–2 per million [1, 4, 5].
1 Introduction Chronic lymphocytic leukemia (CLL) is the most common low-grade B-cell neoplasm, predominantly affecting older adults with a median age at diagnosis of 70 years. It has an age-adjusted incidence of 4.9 per 100 000 person-years, with a higher incidence in European and North American countries, and more commonly affects males (male:female ratio of 1.7:1) [1].
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