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Articles by Igor Sauer
Effect of virtual reality on spatial–anatomical understanding in preoperative liver surgery: a randomized crossover study
Abstract Precise spatial understanding of complex anatomy is critical for preoperative planning in hepatobiliary surgery. Traditional CT and MRI imaging require mental reconstruction of anatomy from 2D slices, imposing substantial cognitive load. Although 3D reconstructions improve spatial understanding, they are typically displayed on 2D screens, limiting true depth perception.
Author Correction: Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection
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Correction to: Nature Communications https://doi.org/10.1038/s41467-026-68397-1, published online 28 January 2026 In the version of this article initially published, there were errors in the Fig. 8 color key, where the current labels (gray: “NR, Low,” black: “NR, high”; and light red: “TCMR, low,” red: “TCMR, high”) were originally interchanged. The figure is now amended in the HTML and PDF versions of the article.
By Anna Maria Pfefferkorn, Lorenz Jahn, Patrick Gauthier, Vera Anna Kulow, Niklas Müller-Bötticher, Janna Leiz, Izabela Plumbom, Robert Greite, Svjetlana Lovric, Jaba Gamrekelashvili, Florian Limbourg, Jessica Schmitz, Jan Hinrich Bräsen, Irina Scheffner, Igor Sauer, Felix Aigner, Janine Altmüller, Thomas Conrad, Wilfried Gwinner, Naveed Ishaque, Michael Fähling, Kai M. Schmidt-Ott, Philip F. Halloran, Muhammad Ashraf, Christian Hinze, Johannes Roeles, Louisa M. S. Gerhardt, Sadia Sarfraz
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Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection - Nature Communications
Abstract T-cell–mediated rejection (TCMR) remains a major cause of kidney transplant failure, despite being considered treatable. Its impact reflects a limited understanding of the underlying molecular mechanisms and their clinical consequences. To address this, we induced acute TCMR in mouse kidney transplants and profiled molecular changes using single-nucleus RNA sequencing (snRNA-seq), spatial transcriptomics and immunofluorescence.
Extracellular NAD+ response to post-hepatectomy liver failure: bridging preclinical and clinical findings - Communications Biology
Abstract Liver fibrosis progressing to cirrhosis is a major risk factor for liver cancer, impacting surgical treatment and survival. Our study focuses on the role of extracellular nicotinamide adenine dinucleotide (eNAD+) in liver fibrosis, analyzing liver disease patients undergoing surgery. Additionally, we explore NAD+’s therapeutic potential in a mouse model of extended liver resection and in vitro using 3D hepatocyte spheroids.
Teburu – Open Source 3D Printable Bioreactor for Tissue Slices as Dynamic Three‐Dimensional Cell Culture Models - Daneshgar - - Artificial Organs - Wiley Online Library
Thoughts & Progress Teburu – Open Source 3D Printable Bioreactor for Tissue Slices as Dynamic Three‐Dimensional Cell Culture Models Michael Lommel Charité – Universitätsmedizin Berlin, Biofluid Machanics Laboratory, Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Campus Virchow‐Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany Search for more papers by this author Ulrich Kertzscher Charité – Universitätsmedizin Berlin, Biofluid Machanics...
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
Abstract All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, including KLRB1, KLRG1, GPR56, and KLRF1, help define low, high, or exhausted cytokine producers within human peripheral and intrahepatic CD4+ memory T-cell populations.
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