Introduction Type 2 diabetes (T2DM) is one of the crucial causes of cardiovascular disease (CVD).1 Endothelial dysfunction and atherosclerosis by oxidative damage and inflammation, which are the significant contributors to macrovascular and microvascular complications of T2DM, lead to an increase in CVD.2, 3 For years, the increased risk of cardiovascular morbidity and mortality has been acknowledged in patients with T2DM; early detection of this risk has been investigated for prevention in...