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Abstract Oncogenic MYC transcription factors profoundly rewire cellular programs, imposing therapeutically exploitable dependencies in MYC‑driven cancers such as high‑risk neuroblastoma. However, dissecting these synthetic lethal vulnerabilities using tunable gene expression remains challenging. Widely used tetracycline-regulated systems rely on inducers known to perturb mitochondrial function, introducing confounding off-target effects.
Abstract Osteosarcoma is the most common bone tumor occurring in children and adolescents. The prognosis of osteosarcoma patients with metastasis is rather poor, availability of prognostic molecular markers would thereby help to distinguish patients with a worse prognosis and to choose appropriate treatment. This study aimed to analyze data from publicly available datasets to identify genes and pathways associated with osteosarcoma onset and metastasis.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.