aInstitution of Clinical Sciences, Department of Neurosciences, Umeå University, Umeå, Sweden bInstitution of Radiation Sciences, Department of Diagnostic Radiology, Umeå University, Umeå, Sweden cSunnybrook Health Science Center, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada dInstitute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg, Sweden eWallenberg Center of Molecular Medicine, Umeå University, Umeå, Sweden