AUC area under the curve cMono classical monocytes COMBAT covidCOVID-19 multi-omics blood atlas DEG differentially expressed genes GO gene ontology HV healthy volunteer ncMono non-classical monocytes PBMCs peripheral blood mononuclear cells PC principal component SASP senescence-associated secretory phenotype UMAP uniform manifold approximation and projection The outbreak of the COVID-19 pandemic caused by the SARS-CoV-2 virus has led to a worldwide health crisis.