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1. Introduction Cerebrovascular disease is a major cause of cognitive impairment and dementia, either alone or in combination with Alzheimer's disease. This vascular contribution to cognitive decline is collectively referred to as vascular cognitive impairment (VCI) [1x[1]Gorelick, P.B., Scuteri, A., Black, S.E., Decarli, C., Greenberg, S.M., Iadecola, C. et al.
Studies on the impact of small vessel disease (SVD) on cognition generally focus on white matter hyperintensity (WMH) volume. The extent to which WMH location relates to cognitive performance has received less attention, but is likely to be functionally important. We examined the relation between WMH location and cognition in a memory clinic cohort of patients with sporadic SVD. A total of 167 patients with SVD were recruited from memory clinics.
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