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Background: Tong–Xie–Yao–Fang (TXYF) is a Chinese herbal formula for treating chronic diarrhoea accompanied by abdominal pain. The results were inconsistent in previous trials examining its effect. Aim: To study the efficacy of TXYF granules for treating diarrhoea–predominant irritable bowel syndrome (IBS–D). Methods: We performed a double–blind, placebo–controlled randomised trial and enrolled 160 participants with IBS–D.
We performed a double‐blind, placebo‐controlled randomised trial and enrolled 160 participants with IBS‐D. The participants had VAS scores ≥3 cm in IBS‐D global symptoms and ≥2 days in a week with abdominal pain and loose stools (Bristol score 5, 6 or 7). They were randomly assigned to received TXYF or placebo during a treatment period of 4 weeks, and they were followed up for 8 weeks after treatment.
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