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Articles by J Yu
Special Issue for Point‐of‐Care Testing
Editorial J Yu, Fei Li, Ming Zhou, PDF ShareShare Abstract As the increase of the world's population, the desired mode of in vitro diagnostics has shifted from the execution in specialist laboratory to self-tests, which can be assigned to one type of the so-called “point-of-care testing (POCT)”. This diagnostic technique helps to tackle the matter of urgency for the place where the clinics are fewer and facilities are often poorly equipped.
Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells
Important for the organization of the cytoskeleton required for migration and possibly planar-cell polarity is hematopoietic-lineage-cell-specific protein 1 (HS1). HS1 is a cytoplasmic protein that can be undergo tyrosine phosphorylation and promote polymerization and rearrangement of the actin cytoskeleton required for cell migration.
Wnt5a induces ROR1 to associate with 14-3-3|[zeta]| for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells
Studies indicated that Wnt5a-induced ROR1-dependent activation of Rho GTPases, RhoA and Rac1, by recruiting guanine-exchange factors (GEFs), such as ARFGEF2. 6 However, ARFGEF2 lacks a SH3 domain, suggesting other proteins are necessary for ARFGEF2 to complex with ROR1. Defining what protein(s) are required for recruitment to ROR1 of GEFs, such as ARFGEF2, could help elucidate the mechanism(s), whereby ROR1 is involved in enhancing migration and proliferation to promote tumor progression.
Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells
This is an unedited manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.
Leukemia - Abstract of article: Wnt5a induces ROR1 to associate with 14-3-3[zeta] for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells
This is an unedited manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.
Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib
We hypothesized that the effects of ibrutinib on blocking BCR-signaling might be offset by non-canonical Wnt-signaling via ROR1. If so, then inhibition of both ROR1- and BCR-signaling might have an enhanced anti-tumor effect. In this study, we investigated whether Wnt5a/ROR1 signaling was affected by treatment with ibrutinib and examined the activity of ibrutinib and cirmtuzumab on CLL cells in vitro and in vivo .
Cirmtuzumab inhibits Wnt5a-induced Rac1-activation in chronic lymphocytic leukemia treated with ibrutinib
This is an unedited manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.
Evaluating “Value” in Metastatic Colorectal Cancer Treatments: Trends in the Evidence
Leading medical professional societies (eg, ASCO, ESMO, NCCN) have recently released frameworks to facilitate discussions on the value of cancer therapies. This literature review summarizes recent trends on the concept of evaluating value in cancer care, using mCRC as an example.
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