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Articles by Jack Wadden
Surgical waste from stereotactic glioma biopsies contains clinically relevant tumor DNA
Abstract Stereotactic needle biopsy is an established approach for sampling gliomas in deep, midline, or eloquent brain regions, but tissue acquisition remains constrained by the need to preserve material for histopathology, molecular testing, and research. During routine specimen handling, needle rinse fluid, expelled aspiration material, and gauze-associated debris are discarded as waste. This waste could contain diagnostically relevant tumor material.
Single-molecule systems for the detection and monitoring of plasma-circulating nucleosomes and oncoproteins in diffuse midline glioma
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ArticleVolume 6, Issue 1101918Open access 1Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel 2Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA 3Department of Radiology, University of Michigan, Ann Arbor, MI, USA 4Center for Genetic Medicine, Children’s National Medical Center, Washington, DC, USA 5Unit of Pediatric Hematology Oncology, The Eisenberg R&D Authority, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew...
By Nir Erez, Noa Furth, Vadim Fedyuk, Jack Wadden, Rayan Aittaleb, Tiffany Adam, Kallen Schwark, Michael Niculcea, Madeline Miclea, Rajen Mody, Andrea T. Franson, Hemant Parmar, Mohannad Ibrahim, Benison Lau, Augustine Eze, Niku Nourmohammadi, Javad Nazarian, Guy Ron, Sriram Venneti, Carl Koschmann, Efrat Shema
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Cell Reports Medicine
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Single-molecule systems for detection and monitoring of plasma circulating nucleosomes and oncoproteins in Diffuse Midline Glioma
Abstract The analysis of cell-free tumor DNA (ctDNA) and proteins in the blood of cancer patients potentiates a new generation of non-invasive diagnostics and treatment monitoring approaches. However, confident detection of these tumor-originating markers is challenging, especially in the context of brain tumors, in which extremely low amounts of these analytes circulate in the patient's plasma.
Immunotherapy in patients with brain metastasis: advances and challenges for the treatment and the application of circulating biomarkers
1 Clinical challenge The brain is one of the most frequent sites of metastases from some types of solid tumors, such as lung, breast cancers and melanoma. The presence of disease in the brain represents a dismal prognosis and devastating complications for the quality of life of oncological patients and can lead to a different evolution in relation to the histological and molecular type, and clinical characteristics of the tumor.
Rapid Real-time Squiggle Classification for Read Until Using RawMap
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
Rapid Real-time Squiggle Classification for Read Until Using RawMap
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
Real-Time, Direct Classification of Nanopore Signals with SquiggleNet
New Results Yuwei Bao, Jack Wadden, John R. Erb-Downward, Piyush Ranjan, Weichen Zhou, Torrin L. McDonald, Ryan E. Mills, Alan P. Boyle, Robert P. Dickson, David Blaauw, View ORCID ProfileJoshua D. Welch doi: https://doi.org/10.1101/2021.01.15.426907 Abstract Oxford Nanopore sequencers provide results in real time as DNA passes through a nanopore and can eject a molecule after it has been partly sequenced.
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