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Special Issue Published as part of The Journal of Organic Chemistry special issue “Chemistry and Biology of Peptides”. Introduction Click to copy section linkSection link copied! Cyclic peptides have emerged as a powerful class of therapeutic agents, combining the high target specificity and favorable toxicity profiles of linear peptides with enhanced structural and functional properties.
Macrocyclization Compatibility for On-Resin 5-Iodo-1,4-Triazole Formation To demonstrate the versatility of our on-resin 5-iodo-1,4-triazole chemistry, we selected four structurally distinct peptide targets: an oxytocin mimetic ( 2 ), a sunflower trypsin inhibitor-1 analogue (SFTI) ( 3 ), a cyclic RGD octapeptide ( 4 ) and somatostatin ( 5 ).
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