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Abstract Cryptococcus is a ubiquitous environmental fungus and frequent colonizer of human lungs. Colonization can lead to diverse outcomes, from clearance to long-term colonization, and to life-threatening meningoencephalitis. Regardless of the outcome, the process starts with an encounter with phagocytes. Using the zebrafish model of this infection, we have noted that cryptococcal cells first spend time inside macrophages before they become capable of pathogenic replication and dissemination.
PLOS ONE, Dec 2022 This is a preview of a remote PDF: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278058&type=printable Lydia Hashemi, McKenzi E. Ormsbee, Prashant J. Patel, Jacquelyn A. Nielson, Joseph Ahlander, Mojgan Padash Barmchi. , PLOS ONE, 2022, Volume 17, Issue 12, DOI: 10.1371/journal.pone.0278058
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