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Abstract PLK4 is a master regulator of centriole biogenesis. Knockdown or complete inhibition of PLK4 results in centrosome depletion. Recently, it was demonstrated that normal cells can tolerate centriole depletion by utilizing acentriolar condensates of pericentriolar material to function as microtubule organizing centers during mitosis.
• CiteScore: CiteScore: 2019: 6.820 CiteScore measures the average citations received per document published in this title. CiteScore values are based on citation counts in a given year (e.g. 2015) to documents published in three previous calendar years (e.g. 2012 – 14), divided by the number of documents in these three previous years (e.g. 2012 – 14).
Interruption of bile acid (BA) homeostasis has been hypothesized for a variety of liver diseases and for drug-induced liver injury (DILI). Consequently, BA is gaining increasing prominence as a potential biomarker.
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