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Loading metrics Open Access Peer-reviewed Research Article Citation: Abdi J, Redegeld F (2025) Toll-like receptor 1/2 activation reduces immunoglobulin free light chain production by multiple myeloma cells in the context of bone marrow stromal cells and fibronectin. PLoS ONE 20(1): e0310395.
Abstract Studies over the past years have provided evidence that Toll-like receptor (TLRs) activation in multiple myeloma (MM) cells induces heterogeneous functional responses including cell growth and proliferation, survival or apoptosis. These effects have been suggested to be partly due to increase in secretion of cytokines such as IL-6 or IFNα among others from MM cells following TLR activation.
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