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CASE SUMMARY We present a case of leptomeningeal disease (LMD) as the first recurrence of breast cancer in a 40-year-old woman with BRCA2 germline mutation. Initially diagnosed in 2017 with left-sided cT2N1 ER-positive, PR-negative, HER-2-negative invasive mammary carcinoma, she received neoadjuvant FEC-D chemotherapy and bilateral mastectomy with immediate reconstruction with near complete pathologic response (ypT1bN0).
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