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Articles by Jake Lin
Early-life immunological and microbial differences between East African and North European children - Communications Medicine
Abstract The urbanization of African populations adopting Westernized lifestyles might be connected to changes in microbial exposure and immune system activity that are harmful to health and increase the risk of non-communicable diseases, such as immune-mediated diseases.
The Belt and Road Initiative A New Zealand Appraisal
Strategy The Belt and Road Initiative (BRI) presents a unique challenge of responding to a Chinese led initiative that could be a platform for furthering regional development and New Zealand’s economic relations with China but one that remains ambiguous, has divided international opinion and that potentially runs counter to some of New Zealand’s engagement principles.
Distinct Transcriptomic Profiles in Children Prior to the Appearance of Type 1 Diabetes-Linked Islet Autoantibodies and Following Enterovirus Infection
Keywords Humans, Child, Autoantibodies, Diabetes Mellitus, Type 1, Transcriptome, Autoimmunity, Insulin, Enterovirus Infections, Islets of Langerhans Abstract Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown.
Identifying Health Conditions in Older Adults in Textual Health Records Using Deep Learning-Based Natural Language Processing
The authors have declared no competing interest. This work was funded by grants (no. 349335 and 349336) from the Research Council of Finland, the Instrumentarium Science Foundation, the Sigrid Juselius Foundation and the Research Council of Finland funding to Tampere University for strategic profiling in health data science (PROFI-6, 2021-2026) and Samfundet Folkhalsan.
Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease:
1. "2021 ESC guidelines on cardiovascular disease prevention in clinical practice". Eur Heart J . 2021;42:34: 3227-3337. 2. "Genetics of 35 blood and urine biomarkers in the UK Biobank". Nat Genet . 2021;53:2: 185-194. 3. "Improved identification of patients with coronary artery disease by the use of new lipid and lipoprotein biomarkers". Am J Cardiol . 2006;97:5: 640-645. 4. "Inflammatory biomarkers in coronary artery disease". J Cardiol . 2009;53:3: 317-333. 5.
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study http://orcid.org/0000-0001-7417-5151Katri Lindfors1, Jake Lin1,2, Hye-Seung Lee3, Heikki Hyöty1, Matti Nykter1, http://orcid.org/0000-0003-4757-2164Kalle Kurppa1,4,5, Edwin Liu6,7, Sibylle Koletzko8,9, Marian Rewers10, William Hagopian11, Jorma Toppari12,13, Annette-Gabriele Ziegler14,15,16, Beena...
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study Katri Lindfors1, Jake Lin1,2, Hye-Seung Lee3, Heikki Hyöty1, Matti Nykter1, Kalle Kurppa1,4,5, Edwin Liu6,7, Sibylle Koletzko8,9, Marian Rewers10, William Hagopian11, Jorma Toppari12,13, Annette-Gabriele Ziegler14,15,16, Beena Akolkar17, Jeffrey P Krischer3, Joseph F Petrosino18, Richard E Lloyd18, Daniel...
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study
Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study http://orcid.org/0000-0001-7417-5151Katri Lindfors1, Jake Lin1,2, Hye-Seung Lee3, Heikki Hyöty1, Matti Nykter1, http://orcid.org/0000-0003-4757-2164Kalle Kurppa1,4,5, Edwin Liu6,7, Sibylle Koletzko8,9, Marian Rewers10, William Hagopian11, Jorma Toppari12,13, Annette-Gabriele Ziegler14,15,16, Beena...
Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies
Genome and Epigenome Petri Pölönen, Juha Mehtonen, Jake Lin, Thomas Liuksiala, Sergei Häyrynen, Susanna Teppo, Artturi Mäkinen, Ashwini Kumar, Disha Malani, Virva Pohjolainen, Kimmo Porkka, Caroline A. Heckman, Patrick May, Ville Hautamäki, Kirsi J.
Hemap: An interactive online resource for characterizing molecular phenotypes across hematologic malignancies
Research Article Petri Pölönen, Juha Mehtonen, Jake Lin, Thomas Liuksiala, Sergei Häyrynen, Susanna Teppo, Artturi Mäkinen, Ashwini Kumar, Disha Malani, Virva Pohjolainen, Kimmo Porkka, Caroline A. Heckman, Patrick May, Ville Hautamäki, Kirsi J.
Nature-derived microbiota exposure as a novel immunomodulatory approach
Aim: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. Materials & methods: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. Results: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity.
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