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Articles by James Mobley
Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk
Abstract Synaptic deficit has emerged as a key early hallmark for neurodegeneration in the visual pathway. The molecular pathway connecting local synaptic deficit with global cell dysfunction and death remains unclear. We have previously shown that α2δ4, an auxiliary subunit of the voltage-gated calcium channel, is targeted to photoreceptor synapses and required for their formation and function. Notably, α2δ4 mutations have been identified in patients with retinal dystrophy.
Outcomes of Brain Metastasis from Lung Cancer
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End of Season Highlights
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The Involvement of Unfolded Protein Response in the Mechanism of Nitrogen Mustard-Induced Ocular Toxicity.
Abstract Nitrogen mustard (NM) is a known surrogate of sulfur mustard-a chemical-warfare agent that causes a wide range of ocular symptoms, from a permanent reduction in visual acuity to blindness upon exposure. Although it has been proposed that the two blistering agents have a similar mechanism of toxicity, the mode of NM-induced cell death in ocular tissue has not been fully explored.
The Involvement of Unfolded Protein Response in the Mechanism of Nitrogen Mustard-Induced Ocular Toxicity
Introduction Sulfur mustard (SM) was extensively used in the military operations of the Iran-Iraq War between 1980 and 1988, affecting over 64,000 individuals (Ghazanfari et al., 2009; Amini et al., 2020). SM exposure causes severe ocular complications, ranging from a permanent reduction in visual acuity to blindness, which can develop in exposed individuals even 40 years postexposure (Feizi, 2019).
as-a-service - Cisco Blogs
Cisco Blogs / as-a-service as-a-service Welcome to the Age of the Partner It’s pretty clear that we’re moving to a world where managed services and as-a-service begin to merge. This calls for an entirely new customer engagement model, one that revolves around partnerships. How IT organizations are thinking about Network as a Service Cisco’s 2022 Global Networking Trends Report explores recent research on how IT leaders and network professionals are thinking about network-as-a-service models.
Cisco Plus: Accelerating Your Business Outcomes with As-a-service
If the last year has taught us anything, it is that every organization must be aligned to move with speed, agility, and scale to achieve required outcomes. You need the flexibility to quickly adapt to changing priorities, both expected and unexpected. With the increase in remote workers, growth in IoT, data privacy and sovereignty challenges, and the rise in cyber threats, traditional networking and security has become even more complex.
Protect yourself from the flu
Cold and flu season is upon us, which means now is the time for you and your family to get flu shots – while you’re at it, use the opportunity to catch up on all needed vaccinations. If you are hesitant to get the flu vaccine, here are some common questions—and their answers—to help you make the right choice. What is the flu? Influenza (flu) is a viral infection spread from person to person. Most respiratory diseases like influenza are spread from children to adults.
Secure Your Cloud Edge with Cisco Services for SD-WAN
In the new digital economy, there is an increased focus on delivery of superior customer experience as a means to competitive advantage. A recent study by Walker Research predicts that, “By 2020, customer experience will overtake price and product as the key brand differentiator.” To support strategies for more effective and agile customer experiences, companies are working to make their applications and services accessible from anywhere, from any device, by moving them to the cloud.
Cisco Business Critical Services: Helping Customers Increase Productivity, Innovation and Cost Savings
Digital transformation is forcing every company to rethink their core business strategies. As a result, IT operations and engineering departments are under more pressure than ever. They are faced with immense expectations to drive business results, while they keep end-users happy, drive costs down, and quickly launch new service capabilities. It’s no wonder companies are struggling to grow and transform when so much is riding on IT to just run the business.
Diet, exercise keys to keeping diabetes under control
Diabetes is one of the most common diseases physicians treat in South Texas. The Centers for Disease Control have determined that about 10 percent of residents in Victoria County, or more than 6,600 people, have diabetes. What is diabetes, and why are physicians so concerned about it? Diabetes occurs when sugar levels in the bloodstream are high. This causes a number of problems in the body, which can lead to stroke, heart attack, blindness and amputations.
James Mobley - The State Port Pilot : Obituaries
Posted: Monday, May 16, 2016 11:03 am | Updated: 11:04 am, Mon May 16, 2016. James Mobley James Mobley died Saturday, May 14, 2016. He was born in Duplin County on June 24, 1945, son of the late Hallie and Eleanor Cole Mobley. He was a member of Zion United Methodist Church. He is survived by his wife, Virginia Lanier Mobley. Graveside services will be held Tuesday, May 17, at 11 a.m. at Zion United Methodist Church Cemetery. Peacock-Newnam & White Funeral and Cremation Service, Southport.
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