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Jamin Byun

As seen in: Nature, BioRxiv, Journal of Clinical Oncology
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Articles by Jamin Byun

Efficacy and Safety of Anselamimab in Immunoglobulin Light Chain Amyloidosis: Results From the Randomized CARES Trials

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By Jamin Byun, Ashutosh D Wechalekar
| Journal of Clinical Oncology Verified
1-3 Misfolded free light chains are cytotoxic and aggregate into fibrils that deposit in target organs, notably in the heart and kidneys.1,2,4 The disease is rapidly progressive, with high early mortality when diagnosed in advanced stages.5-7 Cardiac involvement, the primary determinant of prognosis staged by serum biomarkers of myocardial injury, is common.8,9 Approximately 79% and 21% of patients with AL amyloidosis have lambda and kappa light chain isotypes, respectively.10-12 The organ...
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Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication - Nature Communications

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By Dohoon Lee, Bonil Koo, Jamin Byun, Dong-Yeop Shin, Ji-Joon Song, Siddhartha Jaiswal, Sung-Soo Yoon, Sun Il Kim
| Nature Verified
Abstract The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery of the significance of DNMT3A-destabilizing mutations (DNMT3AINS) in AML, we here investigate the common characteristics of DNMT3AINS AML methylomes through computational analyses.
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AMLs harboring DNMT3A-destabilizing variants show increased intratumor DNA methylation heterogeneity at bivalent chromatin domains

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By Dohoon Lee, Bonil Koo, Seok-Hyun Kim, Jamin Byun
| BioRxiv
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