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Janik Böhnke

As seen in: Stem Cell Reports
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Articles by Janik Böhnke

Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche

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By Niclas Flosdorf, RWTH Aachen, Janik Böhnke, Niklas Lutterbach
| Stem Cell Reports Verified
Highlights • JAK2 V617F iPSCs reflect the myeloid proliferation bias of MPN patients • JAK2 V617F iPSCs show TPO-independent megakaryopoiesis • JAK2 V617F megakaryocytes acquire a proinflammatory and profibrotic phenotype • JAK2 V617F megakaryocytes induce fibrosis in a 3D in vitro bone marrow niche Summary The myeloproliferative disease polycythemia vera (PV) driven by the JAK2 V617F mutation can transform into myelofibrosis (post-PV-MF).
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By Kathrin Olschok, Lijuan Han, Alexandre Theocharides, Angela Maurer, Julian Baumeister, Siddharth Gupta, Peter Boor, Janik Böhnke, Martin Graßhoff, Herdit M. Schüler, Eva Miriam Buhl, Kristina Pannen, Milena Kalmer
| Stem Cell Reports Verified
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