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Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation Peishan Lee, Zilu Zhu, Janna Hachmann, Takuya Nojima, Daisuke Kitamura, Guy Salvesen, Robert C. Rickert The Journal of Immunology February 1, 2017, 198 (3) 1066-1080; DOI: 10.4049/jimmunol.1502518
During a T cell-dependent immune response, formation of the germinal center (GC) is essential for the generation of high-affinity plasma cells and memory B cells. The canonical NF-?B pathway has been implicated in the initiation of GC reaction, and defects in this pathway have been linked to immune deficiencies. The paracaspase MALT1 plays an important role in regulating NF-?B activation upon triggering of Ag receptors.
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