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Keywords Placenta endocannabinoid system preterm birth gestational age metabolomics monoacylglycerols ▒ KEY MESSAGE Gestational age is the dominant driver of placental enndocannabinoid system (ECS) variation across gene and metabolite profiles. Spontaneous preterm placentas reflect earlier maturation, with elevated monoacylglycerols and higher PTGS2 expression under 32 weeks. These data refine ECS change interpretations preterm birth and suggest links to prostaglandin pathways in parturition.
Abstract Precise regulation of inflammatory signaling at the maternal-fetal interface is essential for a healthy pregnancy, yet how the NLRP3 inflammasome is regulated in the placenta during pregnancy and in preterm birth remains poorly understood. We characterized NLRP3 inflammasome-associated signaling in human villous placental tissue from first-trimester (8–11 weeks), preterm (28–<37 weeks), and term (38–40 weeks) pregnancies.
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