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Articles by Jasmijn A. Schrumpf
Farm Dust Exposure Reduces Cytokine‐ and Rhinovirus‐Induced IL‐33 Expression in Bronchial Epithelial Cells
Farm dust reduces expression of IL-33 in rhinovirus-infected and in TNF-α/IFN-γ-exposed airway epithelial cells. This effect is in part mediated through interference with the interferon-gamma receptor-JAK–STAT1 signalling pathway. To the Editor, Pre-school wheeze, attributed to respiratory viral infections, with rhinovirus (RV) being the most important risk factor, may contribute to early-onset asthma development [1, 2].
Farm dust reduces mucin production in rhinovirus‐infected primary bronchial epithelial cells
To the Editor, Growing up on traditional farms is associated with protection against the development of wheezing, respiratory allergies, and asthma.1 Rhinovirus (RV) infections in early life are a substantial risk factor for asthma development and are linked to mucus hypersecretion in the lungs.2, 3 This results in impaired mucociliary clearance, which contributes to obstruction of (small) airways, processes implicated in asthma pathogenesis.4 Interestingly, the protective farm-effect against...
Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence
Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence Gimano D. Amatngalim, Jasmijn A. Schrumpf, Fernanda Dishchekenian, Tinne C.J. Mertens, Dennis K. Ninaber, Abraham C. van der Linden, Charles Pilette, Christian Taube, Pieter S. Hiemstra, Anne M. van der Does European Respiratory Journal Apr 2018, 51 (4) 1701009; DOI: 10.1183/13993003.01009-2017
Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence
AbstractResearch question: It is currently unknown how cigarette smoke-induced airway remodelling affects highly expressed respiratory epithelial defence proteins and thereby mucosal host defence.Methods: Localization of a selected set of highly expressed respiratory epithelial host defence proteins was assessed in well-differentiated primary bronchial epithelial cell (PBEC) cultures.
Aberrant airway epithelial differentiation resulting from cigarette smoke exposure leads to loss of constitutive antimicrobial peptide and protein (AMP) expression | European Respiratory Society
Aberrant airway epithelial differentiation resulting from cigarette smoke exposure leads to loss of constitutive antimicrobial peptide and protein (AMP) expression Pieter S. Hiemstra, Gimano D. Amatngalim, Jasmijn A. Schrumpf, Fernanda Dishchekenian, Tinne C.J. Mertens, Dennis K. Ninaber, Abraham C. van der Linden, Christian Taube, Anne M. van der Does European Respiratory Journal Sep 2016, 48 (suppl 60) PA1819; DOI: 10.1183/13993003.congress-2016.PA1819
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