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ABSTRACT Background: The oral microbiome comprises the microbial communities inhabiting the oral cavity, whereas the oral metabolome reflects the small molecules generated by host and microbial metabolic activity. These systems may provide insight into substance-related physiological disruption, including altered inflammation, immune signaling, and host – microbial interactions.
1 Introduction Salvia miltiorrhiza (Danshen) is one of the most economically important medicinal plants used as a raw material for the production of cardiovascular drugs, human health foods, and cosmetics (Li et al., 2018; Sun et al., 2022). However, consecutive monoculture of Salvia miltiorrhiza results in disease aggravation, poor growth status, yield reduction, and quality deterioration (Liu et al., 2020a).
Abstract Mapping chromatin loops from noisy Hi-C heatmaps remains a major challenge. Here we present DeepLoop, which performs rigorous bias correction followed by deep-learning-based signal enhancement for robust chromatin interaction mapping from low-depth Hi-C data. DeepLoop enables loop-resolution, single-cell Hi-C analysis. It also achieves a cross-platform convergence between different Hi-C protocols and micrococcal nuclease (micro-C).
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