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Articles by Jay Wright
Regioselective Diversification of Aminopyrazoles via Ir-Catalyzed C─H Borylation
1 Introduction Heterocycles remain a central class of privileged molecular architectures, with nitrogen-containing rings featuring in ≥59% of FDA-approved small molecule drugs [1-4]. Among these, aminopyrazoles represent a versatile heteroaromatic motif frequently encountered in medicinal chemistry and drug discovery [5], featuring in therapeutics for parasitic diseases [6-10], cancer [11-15], viral infections [16-18], and many others (Figure 1A) [19-23].
Expected Benefits From Antibacterial Envelope in Different CIED Patient Populations
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BLISTER The acronym “BLISTER” stands for different clinical factors that contribute to the overall score: Blood markers, Lead extraction, Immunocompromised status, Surgery duration, Type of procedure, EGFR, Re-intervention within 2 years BMI body mass index CIED cardiac implantable electronic device CRP C-reactive protein CRT cardiac resynchronization therapy CRT-D cardiac resynchronization therapy with defibrillator EGFR estimated glomerular filtration rate ICD implantable cardiac...
By David Duncker, Christine Virbel Alonso, Mauro Biffi, Francisco Costa Verified, Panagiota Flevari, Andreas Goette, Didier Klug, Emilce Trucco, Andrew Turley Verified, Jay Wright, Edward Maclean, Tobias Tönnis
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Wiley Online Library
Verified
Photo- and Cu-Mediated 11C Cyanation of (Hetero)Aryl Thianthrenium Salts
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Zinc‐Mediated Radiosynthesis of Unprotected Fluorine‐18 Labelled α‐Tertiary Amides
Introduction Molecules labelled with fluorine-18 are widely used as radiotracers in positron emission tomography (PET), a nuclear imaging modality for detecting and staging various diseases and disorders.1, 2 Radiotracers containing primary or secondary C(sp3)−18F bonds are prevalent, as these are readily prepared via nucleophilic substitution reactions with ca.
Automated production of 11C‐labeled carboxylic acids and esters via “in‐loop” 11C‐carbonylation using GE FX synthesis modules
1 INTRODUCTION Positron emission tomography (PET) imaging is a non-invasive modality for imaging biological processes associated with various diseases and disorders, such as cancer, heart disease, and dementia.1, 2 PET utilizes chemical entities functionalized with radioisotopes (radiopharmaceuticals) that emit γ-radiation via ß-decay.
Sequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes
This article describes a sequential Ir/Cu-mediated process for the meta-selective C–H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp2)–H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [18F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochemical yield and radiochemical purity.
Iridium‐Catalysed C−H Borylation of Heteroarenes: Balancing Steric and Electronic Regiocontrol
Abstract The iridium‐catalysed borylation of aromatic C−H bonds has become the preferred method for the synthesis of aromatic organoboron compounds. The reaction is highly efficient, tolerant of a broad range of substituents and can be applied to both carbocyclic and heterocyclic substrates. The regioselectivity of C−H activation is dominated by steric considerations and there have been considerable efforts to develop more selective processes for less constrained substrates.
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