Abstract Objectives The aim of the study was to describe the mucosal histology of the lower esophagus in a general population and study any differences in histological characteristics between people with (1) no gastroesophageal reflux disease (GERD), i.e., neither symptoms (GERS) nor esophagitis (reference group); (2) non-erosive reflux disease (NERD); (3) no GERS but endoscopic esophagitis; and (4) symptomatic esophagitis, i.e., both GERS and endoscopic esophagitis.