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Abstract Timothy syndrome (TS) is a multisystem disorder with autistic-like features, seizures and life-threatening arrhythmias. Most TS cases are caused by a de novo missense mutation in the CACNA1C gene that encodes the pore-forming subunit of the voltage-gated L-type calcium channel CaV1.2. Patients show highly variable clinical presentations and survival, which may be impacted by acute episodes of hypoglycemia and respiratory dysfunction.
EditorialA Tribute to Roy JacksonAuthorsSankaran Sundaresan,Norman John Sollenberger Professor in EngineeringDepartment of Chemical and Biological Engineering, Princeton UniversitySearch for more papers by this authorChristine M. Hrenya,Associate Editor, AIChE Journal, Professor of Chemical and Biological EngineeringUniversity of Colorado BoulderSearch for more papers by this authorMichael P.
The current study presents experiments for the initial stages of fluidization induced by a localized fluid injection. The process was studied by recording high-speed videos in a 2D-region far from the boundaries using Planar Laser Induced Fluorescence and Refractive Index Matching. The experimental setup allowed for several parameters to be systematically studied including particle sizes, initial bed heights, and injection port diameters.
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