This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1,*,†, 1 and 2,*,† 1 Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg University Hospital, 97080 Würzburg, Germany 2 Infochemistry Scientific Center, Laboratory of Chemoinformatics, ITMO University, Saint Petersburg 191002, Russia * Authors to whom correspondence should be addressed. † Authors contributed equally to this work.