Abstract Diversified Groebke-Blackburn-Bienaymé Approach: Diversity-oriented synthesis of cyclophanyl-derived fused imidazo[1,2-a]heterocycles by one-pot Groebke-Blackburn-Bienaymé (GBB) three-component reaction employing formyl-cyclophane components in combination with various aliphatic and aromatic isocyanides and different heteroaromatic amidines is described. Additionally, a one-pot protocol for the GBB 3CR process by an in-situ generation of cyclophanyl isocyanide is demonstrated.
