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Abstract Different ways of combining virus vector-based vaccines can impact the effectiveness of immune responses against specific antigens. In this study, we explored the effects of different immunization schedules on immune responses elicited by viral vector-based vaccines in monkeys, with a focus on the heterologous regimens with a next-generation attenuated vaccinia virus, Sementis Copenhagen vector (SCV), and human adenovirus serotype 26 (Ad26) expressing the Ebola glycoprotein (EBOV-GP).
Abstract Newly approved subunit and mRNA vaccines for respiratory syncytial virus (RSV) demonstrate effectiveness in preventing severe disease, with protection exceeding 80% primarily through the generation of antibodies. An alternative vaccine platform called self-amplifying RNA (saRNA) holds promise in eliciting humoral and cellular immune responses.
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