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1 Introduction Bladder cancer is the tenth most common malignancy in the world [1], and the fourth most common in men in the United States [2]. Urothelial carcinoma (UC) is the most common pathologic subtype of bladder cancer, and the 2022 WHO update on urothelial tumours expands the list of subtypes (occurring either in pure or mixed form) that are morphologically distinct and have prognostic significance [3, 4].
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