1Department of Gastroenterology, Yangzhou Dong Fang Hospital, Yangzhou, Jiangsu, China 2Department of Gastroenterology, Tianchang People's Hospital, Chuzhou, Anhui, China 3Department of Gastroenterology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China Background and objective: In recent years, the use of high-dose dual therapy based on PPI and amoxicillin (PPI-HDDT) has shown satisfactory efficacy in eradicating Helicobacter pylori (H. pylori) as a first-line treatment.