Abstract Background: Elevated Neutrophil extracellular traps (NETs) associated biomarkers have been documented in inflammatory bowel disease (IBD) patients and preclinical models, but the therapeutic potential of targeting NETs remains unclear. This systematic review summarizes NETs-associated biomarkers in IBD patients and evaluates NETs-targeted interventions in preclinical models. Methods: Following PRISMA guidelines, we searched databases up to November 2025.
