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Articles by Jiacan Su
The sixth sense of the brain: interoception in organoid study
Abstract Interoception is the process by which the nervous system senses, integrates, and interprets signals arising from within the body, thereby enabling the brain to monitor and regulate physiological functions. Often described as a “sixth sense”, interoception links internal physiological states to brain-mediated homeostatic control, whereas sight, smell, hearing, taste, and touch primarily convey information from the external environment.
Decoding mechanoregulation in immunological synapses using biomimetic artificial cells
Abstract Mechanical force-driven signaling has emerged as a key regulator of cell–cell interactions (CCIs), which can enhance immune cell function. However, current biochemical approaches for studying CCIs offer minimal direct control over cellular bulk phenotypes, while synthetic biomaterial systems fail to mimic the dynamic complexity of cells.
Composite MOF hydrogel reprograms bacterial pigment metabolism for eliminating antibiotic-tolerant bacteria
Keywords MRSA antibiotic tolerance bacterial pigment metabolism MOF phototherapy hydrogel thymol vancomycin cuproptosis biofilm Introduction Recently, the inappropriate use of antibiotics has led to a significant increase in multidrug-resistant bacterial infections, posing a major public health threat.
Parabiosis, Assembloids, Organoids (PAO) (Adv. Sci. 7/2026)
Graphical Abstract Parabiosis, Assembloids, Organoids Inspired by the legend of “Taishang Laojun”, the “Bagua Furnace” symbolizes the origin of life and scientific creation. From it emerge three artifacts: “Vajra Ring” for Parabiosis, “Purple Gold Gourd” for Assembloids, and “Jade Flask” for Organoids, tracing PAO progression from systemic to organ and multi organ levels. The three legs denote artificial intelligence, soft robotics, and gene editing.
Parabiosis, Assembloids, Organoids (PAO)
1 Introduction The research and treatment of major diseases such as cancer, neurodegenerative disorders, cardiovascular diseases, and infectious diseases present significant challenges to global public health. These complex conditions require multi-level research models spanning molecular, cellular, and systemic scales. However, existing models exhibit critical limitations in addressing complex biological processes.
Cell Proliferation | Cell Biology Journal | Wiley Online Library
2D two-dimensional 3D three-dimensional AAV adeno-associated viruses ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs AI artificial intelligence AlgMA alginate methacrylate BMSCs bone marrow stromal cells DIO2 type II iodothyronine deiodinase DL deep learning DLP digital light processing DMSO dimethyl sulfoxide ECM extracellular matrix ECs endothelial cells EPCs endothelial progenitor cells EpPs lymphoid progenitor cells ESCs embryonic stem cells GAGs glycosaminoglycans...
Advanced glycation end products mediate biomineralization disorder in diabetic bone disease
Keywords diabetes bone disease bone quality biomineralization bone fracture advanced glycation end products AGEs collagen mineralization aminoguandine metformin type 2 diabetes mellitus Introduction Diabetes mellitus, particularly type 2 diabetes (T2D), presents a multifaceted challenge to bone health.1 Patients with T2D have a 1.9-fold higher risk of fractures compared to non-diabetic individuals.2,3 Paradoxically, despite exhibiting higher BMD, individuals with diabetes demonstrate a higher...
Functional anti-bone tumor biomaterial scaffold: constrcution and application
Bone tumors, including primary bone tumors and bone metastases, have been plagued by poor prognosis for decades. Although most tumor tissue is removed, clinicians are still confronted with the dilemma of eliminating residual cancer cells and regenerating defective bone tissue after surgery. Therefore, functi
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