1 Introduction The incidence of drug-induced liver injury (DILI) has risen recently due to drug abuse, inappropriate clinical use, and lack of public awareness.[1] The rapid and often concealed onset of DILI can lead to irreversible damage.[2, 3] Significant causes of DILI include acetaminophen (APAP) abuse and long-term use of the Chinese herbal medicine Tripterygium wilfordii.[4-6] Both acute APAP-induced and chronic Tripterygium wilfordii-induced liver injuries are characterized by...