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Abstract Background: To compare the efficacy and safety of a bismuth-containing quadruple therapy comprising the novel proton pump inhibitor (PPI) anaprazole versus the classical PPI rabeprazole, both combined with amoxicillin and furazolidone, for Helicobacter pylori (H. pylori) eradication. Methods: A prospective, multicenter, randomized, open-label, non-inferiority design was employed. Consecutive treatment-naïve patients positive for H.
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