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Abstract Aberrant nucleocytoplasmic transport is linked to tumorigenesis. AGGF1 exerts nuclear tumor-suppressing functions, yet how its nuclear import is regulated remains unclear. Through deletion mapping and point mutations, we identified three motifs (272–279, 317–328 and 509–519 aa) governing AGGF1 nucleocytoplasmic distribution. Knockdown of importin β1 and inhibition of importin α1 showed that the importin α1/β1 complex is the primary nuclear import receptor.
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