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Abstract Objective: To validate whether serum levels of absent in melanoma 2 (AIM2) and caspase-5 can serve as early combined biomarkers of unfavorable prognosis in children with lobar pneumonia. Methods: From February 2022 to June 2025, 475 children aged 1–14 years with first-episode lobar pneumonia were prospectively enrolled at Hebei Children's Hospital.
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