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Jianing Bi

As seen in: Nature, Wiley Online Library
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Articles by Jianing Bi

Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma

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By Shuo Liu, Mengrui Liu, Zhenzhen Wang, Shiqi Hu, Kaiyue Zhang, Chao Lu, Xiao Cheng, Ming Shen, Jianing Bi, Dashuai Zhu, Ke Cheng
| Nature Verified
Abstract Cancer immunotherapy with immune checkpoint inhibitors (ICIs) is often limited by an immunosuppressive tumor microenvironment (TME). Simultaneous targeting of the TME and immune checkpoints is a promising approach to address this limitation. Here we develop an inhalable exosome system that enables co-display of two inhibitory ligands and apply it to treat lung metastases of ICI-resistant melanoma.
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Associations of childhood and adulthood body size, and child‐to‐adult body size change with adult telomere length

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By Qing Liu, Qing Yi Fang, Gaojie Fan, Jianing Bi
| Wiley Online Library Verified
Aim To comprehensively examine the associations of childhood and adulthood body size, and child-to-adult body size change with adult leucocyte telomere length (LTL). Methods We included 453 602 participants from the UK Biobank. Childhood body size at the age of 10 years was collected through a questionnaire. Adulthood body size was assessed using body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), fat mass index (FMI), and fat-free mass index (FFMI).
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