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Jianya Huang

As seen in: Nature, Wiley Online Library, Dove Medical Press
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Articles by Jianya Huang

Extracellular vesicle-encapsulated GDF15 alleviates doxorubicin-induced cardiotoxicity via the SUB1/TERT/TPP signalling axis

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By Qingqing Gu, Qianwen Chen, Ye Deng, Li Deng, Jianya Huang, Jingyi Wang, Yuan Ji, Ruxing Wang, Qingjie Wang, Ling Sun
| Nature Verified
Abstract Doxorubicin (DOX) is a highly effective chemotherapeutic agent, but its clinical application is limited by cardiotoxicity. Mitochondrial dysfunction and apoptosis are key mechanisms underlying DOX-induced cardiomyopathy (DIC), while the role of telomerase reverse transcriptase (TERT) and its specific regulatory mechanisms remain unclear. An in vitro DOX-induced H9C2 cardiomyocyte injury model was established. TERT was overexpressed via adenoviral transfection or inhibited using BIBR1532.
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A Prospective Cohort Study on the Impact of SGLT2 Inhibitors on the 12‑Month Recurrence Risk of Atrial Fibrillation After Catheter Ablation

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By Jianya Huang, Ye Deng, Yiqiu Gu
| Dove Medical Press
Back to Journals » Drug Design, Development and Therapy » Volume 20 Authors Huang J, Gu Y, Deng Y, Miao Y, Deng L, Wang J , Zhang Y, Wei J, Sun L , Ji Y, Wang Q Received 12 November 2025 Accepted for publication 18 March 2026 Published 25 March 2026 Volume 2026:20 Pages 1—14 DOI https://doi.org/10.2147/DDDT.S580640 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Anastasios Lymperopoulos Jianya Huang,1,*...
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C‐Reactive Protein-Albumin-Lymphocyte (CALLY) Index as an Independent Risk Factor for Postoperative Atrial Fibrillation Recurrence

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By Ye Deng, Jianya Huang, Li Deng, Yuxuan Zhou
| Wiley Online Library Verified
1 Introduction Atrial fibrillation (AF), the predominant clinical arrhythmia worldwide, constitutes a major healthcare burden due to its strong association with thromboembolic events and cardiac dysfunction [1]. Epidemiological projections indicate China will face approximately 9 million AF cases among individuals ≥ 60 years by 2050, underscoring the urgency for effective management [2].
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Reference Interval Establishment for Neutrophil‐To‐Lymphocyte Ratio, Platelet‐To‐Lymphocyte Ratio, and Systemic Immune‐Inflammation Index in Athletes: Analysis of Sex and Sport Type Impact

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By Cong Wang, Qi Lu, Zhengmei Ning, Jianya Huang
| Wiley Online Library Verified
1 Introduction The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are widely recognized as reliable biomarkers for assessing immune function and systemic inflammation in both clinical and athlete populations [1-4]. These indices, derived from routine blood tests, can reflect variations in immune responses driven by physiological stress, hormonal factors, and training loads.
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