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Jiayue Su

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Articles by Jiayue Su

Syndecan-3 couples tumor mechanics to immunosuppressive macrophage identity

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By Caihua Zhang, Maosheng Cheng, Shuang Chen, Gan Xiong, Xin Zhe Liu, Rongsong Ling, Jiayue Su, Cheng Wang, Cun-Yu Wang, Demeng Chen
| Nature Verified
Abstract Tumor-associated macrophages adopt suppressive states, but how tumor stress installs these programs remains unclear. Here, we identify syndecan-3 (SDC3) as a macrophage-intrinsic mechanosensory regulator by integrating in vivo functional screening, single-cell and spatial profiling, and genetic and pharmacological perturbation. SDC3+ macrophages accumulate in hypoxic, stiff tumor niches and suppress antitumor cytotoxic T-cell responses.
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Structural insight into synergistic activation of human 3-methylcrotonyl-CoA carboxylase - Nature Structural & Molecular Biology

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By Jiayue Su, Hang Cheng, Shan Sun, Hong-Wei Wang
| Nature Verified
Abstract The enzymes 3-methylcrotonyl-coenzyme A (CoA) carboxylase (MCC), pyruvate carboxylase and propionyl-CoA carboxylase belong to the biotin-dependent carboxylase family located in mitochondria. They participate in various metabolic pathways in human such as amino acid metabolism and tricarboxylic acid cycle. Many human diseases are caused by mutations in those enzymes but their structures have not been fully resolved so far.
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Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s

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By Jiao Yang, Yinong Zong, Jiayue Su, Hongtao Li
| Nature Verified
We have obtained a new crystal structure of human BiP containing both functional domains at 1.85?Å in the presence of ATP (Fig. 1, Table 1, and Supplementary Figs. 1, 2a–c). Unlike all previously reported Hsp70-ATP structures28, 29, 31, 34, this new BiP-ATP structure, BiP-ATP2, has an entirely wild-type (WT) NBD. It does not carry the ATPase-deficient T229A mutation (T199A in DnaK)28, 37, which has helped maintain the ATP-bound state in all previously reported Hsp70-ATP structures28, 29, 31, 34.
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