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Abstract Neuroblastoma (NB) is an aggressive pediatric cancer with poor high‑risk prognosis. MYCN amplification (MNA) is an established high-risk biomarker but is present in only approximately 20% of patients. Consistent with recent studies, our results showed that high MYCN expression, observed in approximately 60% of high-risk patients, serves as a more prevalent biomarker for high-risk NB, although its upstream regulatory mechanism remains incompletely understood.
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