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Understanding genetic variation is fundamental in the study of human evolution and genetic diseases. The first human reference genome, revealed by the Human Genome Project, allowed geneticists to study genetic variation between individuals at the genome level, leading to rapid advancement in targeted and whole-genome sequencing technologies (1–7).
We used three WGS datasets: the general, downsampled, and external datasets (See Supplementary Table S1). For the general dataset, we used one NA12878 and two HG00514 samples whose raw datasets were downloaded from the National Center for Biotechnology Information Sequence Read Archive (SRA, https://www.ncbi.nlm.nih.gov/sra).
Hormones and Cancer, Mar 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s12672-023-00643-0.pdf Ju, Won Seok, Seo, Sang Young, Mun, Seong-eun, Kim, Kyongtae, Yu, Jin Ok, Ryu, Jae-Sung, Kim, Ji-Su, Choo, Young-Kug. , Hormones and Cancer, 2023, pp. 1-13, Volume 14, Issue 1, DOI: 10.1007/s12672-023-00643-0
Defective gut immune reactions have been implicated in the development of atopic dermatitis (AD), whereas oral tolerance (OT), i.e., the immune unresponsiveness induced by oral antigen administration, protects mice against AD. To investigate this protective role of OT, the transcriptomic profiles of skin were obtained by RNA sequencing from mice that were epicutaneously sensitized, orally tolerized prior to epicutaneous sensitization, or neither (control).
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