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Abstract Background: The optimal noninvasive respiratory support strategy for very preterm infants among NCPAP, NIPPV, NHFOV, HFNC, and NIV-NAVA remains unclear. Methods: This network meta-analysis of nine randomized controlled trials involving 1,449 preterm infants compared the efficacy and safety of these five modes evaluated in eight trials of early respiratory support and one trial of support after clinical stabilization.
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