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Jixuan Sun

As seen in: Color Research & Application, Frontiers
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Articles by Jixuan Sun

Placebo-associated changes in MRI-PDFF and metabolic parameters in MASLD patients from phase Ib/IIa clinical trials: implications for early-phase trial design and translational endpoint interpretation

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By Mengdi Lu, Hong Ping Zhang, Xiaoxue Zhu, Jia Xu, Lin Xiang, Yue Hu, Jixuan Sun, Jiajia Mai, Yanhua Ding
| Frontiers
Abstract Background: The placebo effect in early-phase metabolic dysfunction–associated steatotic liver disease (MASLD) trials is poorly defined but may substantially influence endpoint interpretation and proof-of-concept decisions. A ≥30% relative reduction in magnetic resonance imaging–proton density fat fraction (MRI-PDFF) is an established noninvasive surrogate of histologic improvement.
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Pharmacokinetics, safety, and immunogenicity of HLX03, an adalimumab biosimilar, compared with reference biologic in healthy Chinese male volunteers: Results of a randomized, double‐blind, parallel‐controlled, phase 1 study - Zhang - 2021 - Pharmacology R

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By Hong P. Zhang, Min Wu, Xiaoxue Zhu, Jixuan Sun
| Color Research & Application Verified
Abbreviations %AUCex area under the concentration curve extrapolated from time 0 to infinity ADAs antidrug antibodies AEs adverse events ALT alanine aminotransferase AS ankylosing spondylitis AST aspartate aminotransferase AUC0–inf area under the concentration curve from time zero to infinity AUC0–t area under the concentration curve from time zero to the last quantifiable concentration BMI body mass index CD Crohn's disease CI confidence interval CL clearance Cmax maximum observed plasma...
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