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1 Introduction Prostate cancer (PCa) ranks the second highest globally in terms of the prevalence of male malignancies, with more than 1.4 million new cases diagnosed in 2020 (1). High-risk PCa accounts for over one-third of the newly diagnosed PCa population, with a three-fold greater risk of developing distant metastasis compared to their low-risk counterparts. The management strategies of these two cohorts differ drastically.
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